Huang Aj et al. Persistent Hot Flushes in Older Postmenopausal Women. Arch Intern Med 28 April 2008;168(8):840-846.
This cohort study was conducted by US authors to examine the prevalence, natural history, and predictors of hot flushes in older postmenopausal women. They surveyed 3167 older women with osteoporosis using a questionnaire and followed up after 3 years. Logistic regression was used to identify characteristics associated with symptoms at baseline and after 3 years of follow-up.
At baseline, 375 women (11.8%) reported bothersome hot flushes. Women were more likely to have baseline symptoms if they were less educated (OR 1.28), more recently menopausal (OR, 1.44), had previously used estrogen (OR, 1.57), or had undergone hysterectomy (OR, 1.51). Hot flushes were also associated with higher body mass index (OR, 1.22), higher follicle- stimulating hormone levels (OR, 1.34), lower high-density lipoprotein levels (OR, 1.17), vaginal dryness (OR, 1.52), and trouble sleeping (OR, 2.48), but not estradiol levels. Of the 375 women with baseline symptoms, 278 contributed 3-year data, and 157 (56.5%) of these women reported persistent symptoms after 3 years. Fewer years since menopause (OR, 1.15) and trouble sleeping (OR, 1.97) were associated with symptom persistence.